The main story mode of the game. You'll follow one survivor through a dozen cities that get progressively bigger and harder.
| City | Difficulty | Size | Factions | Rivers | Coastline | Notes |
|---|---|---|---|---|---|---|
| Snoqualmie | Easy | Small | 0 | No | No | |
| Wenatchee | Normal | Typical | 2 | Yes | No | Leader Perk event, the Agabayani research can be obtained in this city |
| Moses Lake | Normal | Typical | 2 | No | Yes | Leader Perk event |
| Spokane | Normal | Big | 3 | Yes | No | Leader Perk event |
| Trail | Normal | Small | 1 | No | No | |
| Nelson | Challenging | Big | 4 | No | Yes | Leader Perk event |
| Castlegar | Challenging | Typical | 3 | Yes | No | Antivenom can be researched in this city. |
| Pentiction | Challenging | Big | 4 | Yes | Yes | The European data dump can be obtained in this city. Antivenom can be researched in this city. |
| Kelowna | Challenging | Big | 4 | No | Yes | Leader Perk event, Antivenom can be researched in this city |
| Hope | Challenging | Typical | 2 | No | No | |
| Chilliwack | Hard | Big | 4 | Yes | No | Leader Perk event |
| Abbotsford | Hard | Huge | 5 | Yes | No | Cure studied in this city. The Monkey Blood sidequest must be completed before this for alternate ending. |
| Vancouver | Hard | Huge | 8 | Yes | Yes | Everything falls apart |